FEATURES

FAMILY

DESCRIPTION

Also known as PTPRF_HUMAN, PTPRF, LAR. Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity., The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTPRF

Receptor-type tyrosine-protein phosphatase F

PTPRF

Molecular Synopsis