FEATURES

FAMILY

DESCRIPTION

Also known as THA_HUMAN, THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2. Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine., Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (PubMed:20078863).

Also known as THA_HUMAN, THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2. Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, ...

EXTERNAL LINKS

THRA

Thyroid hormone receptor alpha

THRA

Molecular Synopsis