FEATURES

FAMILY

DESCRIPTION

Also known as ENTF_ECOLI, entF. Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2, 3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2, 3-dihydroxybenzoate by EntE). EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase. EntF acts as a catalytic monomer.

EXTERNAL LINKS

uniprot
enzyme classification

entF

Mutations

Mutation(s) distribution

Mutations table