FEATURES

DESCRIPTION

Also known as MPRD_BOVIN, M6PR. Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Homodimer. Interacts with GGA1, GGA2 and GGA3 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

M6PR

Cation-dependent mannose-6-phosphate receptor

M6PR

Molecular Synopsis