FEATURES

FAMILY

paramyxoviruses hemagglutinin-neuraminidase family

DESCRIPTION

Also known as HN_NDVU, HN. Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion., Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. Homodimer. Forms homotetramers. Interacts with fusion/F protein. Interacts with host CG-1B; this interaction inhibits viral adsorption and replication rather than internalization.

EXTERNAL LINKS

HN

Hemagglutinin-neuraminidase

HN

Molecular Synopsis