FEATURES

FAMILY

DESCRIPTION

Also known as CCL2_HUMAN, CCL2, MCP1, SCYA2. Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). Monomer or homodimer; in equilibrium (PubMed:8898111, PubMed:9837883, PubMed:15033992, PubMed:8989326). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674).

Also known as CCL2_HUMAN, CCL2, MCP1, SCYA2. Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 an ...

EXTERNAL LINKS

CCL2

C-C motif chemokine 2

CCL2

Molecular Synopsis