FEATURES

FAMILY

DESCRIPTION

Also known as CO6_HUMAN, C6. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

C6

Complement component C6

Mutations

Mutation(s) distribution

Mutations table

Search Mutation