FEATURES

FAMILY

DESCRIPTION

Also known as FPPS_HUMAN, FDPS, FPS, KIAA1293. Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Homodimer. Interacts with RSAD2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FDPS

Mutations

Mutation(s) distribution

Mutations table