FEATURES

DESCRIPTION

Also known as MCP_HUMAN, CD46, MCP, MIC10. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity., (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells., (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3., (Microbial infection) Acts as a receptor for cultured Measles virus., (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6., (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006). Interacts with C3b (PubMed:3260937, PubMed:1717583). Interacts with C4b (PubMed:1717583). Interacts with moesin/MSN (PubMed:7884872).

Also known as MCP_HUMAN, CD46, MCP, MIC10. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b ...

EXTERNAL LINKS

CD46

Membrane cofactor protein

CD46

Molecular Synopsis