FEATURES

FAMILY

archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family

DESCRIPTION

Also known as RPB3_YEAST, RPB3. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

EXTERNAL LINKS

RPB3

Mutations

Mutation(s) distribution

Mutations table