FEATURES

FAMILY

DESCRIPTION

Also known as DPEP1_HUMAN, DPEP1, MDP, RDP. Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084)., Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver. Homodimer; disulfide-linked.

Also known as DPEP1_HUMAN, DPEP1, MDP, RDP. Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408). H ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DPEP1

Mutations

Mutation(s) distribution

Mutations table