FEATURES

FAMILY

DESCRIPTION

Also known as EF3A_YEAST, YEF3, EFC1, TEF3, YEF3A. Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (PubMed:7657623, PubMed:6456269, PubMed:29300771). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (PubMed:7657623). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (PubMed:7657623). Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation on ribosomes by reducing GCN1-ribosome affinity, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved or repleted cells (PubMed:22888004). Monomer. Interacts with elongation factor 1A (eEF1A). Interacts through its N-terminus with 18S rRNA. Associates with ribosomes (PubMed:22888004).

Also known as EF3A_YEAST, YEF3, EFC1, TEF3, YEF3A. Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (PubMed:7657623, PubMed:6456269, PubMed:29300771). Required for ...

EXTERNAL LINKS

YEF3

Mutations

Mutation(s) distribution

Mutations table