FEATURES

FAMILY

DESCRIPTION

Also known as UL128_HCMVA, UL128. Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection. Additionally, monomeric UL128 may interfere with certain inflammatory cytokines to increase infection and dissemination by blocking monocytes migration. Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A (PubMed:28783665). The pentamer interacts with host NRP2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

UL128

Uncharacterized protein UL128

UL128

Molecular Synopsis