FEATURES

FAMILY

DESCRIPTION

Also known as PTPRA_HUMAN, PTPRA, PTPA, PTPRL2. Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain), and SRC (PubMed:22801373). Within the complex, interacts (when phosphorylated on Tyr-798) with BCAR3 (via SH2 domain) (PubMed:22801373). Interacts with GRB2 (PubMed:22801373).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTPRA

Receptor-type tyrosine-protein phosphatase alpha

PTPRA

Molecular Synopsis