FEATURES

FAMILY

DESCRIPTION

Also known as PACA_HUMAN, ADCYAP1. Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADCYAP1

Pituitary adenylate cyclase-activating polypeptide

Mutations

Mutation(s) distribution

Mutations table

Search Mutation