FEATURES

FAMILY

glutamate-gated ion channel (TC 1.A.10.1) family

DESCRIPTION

Also known as GRIA1_RAT, Gria1, Glur1. Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (PubMed:21639859). Tetramers may be formed by the dimerization of dimers (By similarity). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus) (PubMed:12070168, PubMed:17069616, PubMed:9677374). Interacts with LRFN1 (PubMed:16630835). Interacts with PRKG2 (PubMed:18031684). Interacts with CNIH2 and CACNG2 (PubMed:20805473). Interacts with CACNG5 (PubMed:18817736, PubMed:19234459). Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes (PubMed:15456832). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (PubMed:16793768, PubMed:19265014). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).

EXTERNAL LINKS

Gria1

Mutations

Mutation(s) distribution

Mutations table