FEATURES

DESCRIPTION

Also known as ELAF_HUMAN, PI3, WAP3, WFDC14. Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PI3

Mutations

Mutation(s) distribution

Mutations table