FEATURES

DESCRIPTION

Also known as MBL1_RAT, Mbl1. Calcium-dependent lectin (PubMed:1436090, PubMed:9033386, PubMed:11850428). Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (PubMed:3584121). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). Homotrimer (PubMed:7704532, PubMed:9033386, PubMed:11850428, PubMed:25419660). Forms higher oligomeric complexes formed by the association of two, three or more homotrimers (PubMed:10903744, PubMed:25419660). Oligomerization occurs in the endoplasmic reticulum (By similarity). Interacts with MASP1 and MASP2 (PubMed:10913141).

EXTERNAL LINKS

Mbl1

Mutations

Mutation(s) distribution

Mutations table