FEATURES

DESCRIPTION

Also known as TNR1B_HUMAN, TNFRSF1B, TNFBR, TNFR2. Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2 (PubMed:8069916, PubMed:10206649). Interacts with BMX (PubMed:12370298). Interacts (activated form) with XPNPEP3 (PubMed:25609706).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TNFRSF1B

Tumor necrosis factor receptor superfamily member 1B

TNFRSF1B

Molecular Synopsis