FEATURES

FAMILY

DESCRIPTION

Also known as RECO_BOVIN, RCVRN, RCV1. Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (PubMed:1672047, PubMed:1672637). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (PubMed:1672047, PubMed:1672637, PubMed:8392055, PubMed:16675451, PubMed:21299498, PubMed:12686556, PubMed:17015448). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). Homodimer; disulfide-linked (PubMed:25772009). Homodimerization is caused by prolonged intense illumination (PubMed:25772009). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (PubMed:17020884). Interacts (via C-terminus) with GRK1 (via N-terminus); the interaction is Ca(2+)-dependent (PubMed:16675451, PubMed:21299498, PubMed:24189072, PubMed:26584024).

EXTERNAL LINKS

RCVRN

Mutations

Mutation(s) distribution

Mutations table