FEATURES

FAMILY

L-isoaspartyl/D-aspartyl protein methyltransferase family

DESCRIPTION

Also known as PIMT_HUMAN, PCMT1. Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. Monomer.

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EXTERNAL LINKS

PCMT1

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

ligandability Mutations

PCMT1

Molecular Synopsis