FEATURES

FAMILY

L-isoaspartyl/D-aspartyl protein methyltransferase family

DESCRIPTION

Also known as PIMT_HUMAN, PCMT1. Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PCMT1

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

PCMT1

Molecular Synopsis