FEATURES

FAMILY

DESCRIPTION

Also known as MUKB_ECOLI, mukB. Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ. Identified in a complex with SpoT; IscS and ACP. Interacts with the ParC subunit of topoisomerase IV.

EXTERNAL LINKS

mukB

Chromosome partition protein MukB

mukB

Molecular Synopsis