FEATURES

FAMILY

DESCRIPTION

Also known as XPA_HUMAN, XPA, XPAC. Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1. Interacts with RPA1 and RPA2; the interaction is direct and associates XPA with the RPA complex. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

XPA

DNA repair protein complementing XP-A cells

XPA

Molecular Synopsis