FEATURES

FAMILY

DESCRIPTION

Also known as NKX21_RAT, Nkx2-1, Nkx-2.1, Titf1, Ttf-1, Ttf1. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123). Interacts with WWTR1.

Also known as NKX21_RAT, Nkx2-1, Nkx-2.1, Titf1, Ttf-1, Ttf1. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and th ...

EXTERNAL LINKS

Nkx2-1

Structural Ligandability

Domains Chains

Distribution