FEATURES

FAMILY

DESCRIPTION

Also known as PTPRZ_HUMAN, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ. Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity). Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity).

Also known as PTPRZ_HUMAN, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ. Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Requir ...

EXTERNAL LINKS

PTPRZ1

Receptor-type tyrosine-protein phosphatase zeta

PTPRZ1

Molecular Synopsis