FEATURES

FAMILY

DESCRIPTION

Also known as THI4_FUSOX, sti35. Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. Homooctamer.

EXTERNAL LINKS

uniprot
enzyme classification

sti35

Thiamine thiazole synthase

sti35

Structural Ligandability

Domains Chains

Distribution