FEATURES

DESCRIPTION

Also known as TNR5_HUMAN, CD40, TNFRSF5. Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CD40

Tumor necrosis factor receptor superfamily member 5

CD40

Molecular Synopsis