FEATURES

FAMILY

DESCRIPTION

Also known as AVR2A_MOUSE, Acvr2a, Acvr2. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527). Interacts with type I receptor ACVR1 (By similarity). Interacts with BMP7 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Acvr2a

Mutations

Mutation(s) distribution

Mutations table