FEATURES

FAMILY

DESCRIPTION

Also known as VATL_HUMAN, ATP6V0C, ATP6C, ATP6L, ATPL. Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.

EXTERNAL LINKS

ATP6V0C

V-type proton ATPase 16 kDa proteolipid subunit

ATP6V0C

Molecular Synopsis