FEATURES

FAMILY

DESCRIPTION

Also known as WNT8_XENLA, wnt8. Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone. Homooligomer; disulfide-linked, leading to inactivation. Interacts with the long chain of cer1.

EXTERNAL LINKS

uniprot
enzyme classification

wnt8

Mutations

Mutation(s) distribution

Mutations table