FEATURES

FAMILY

DESCRIPTION

Also known as ELK4_HUMAN, ELK4, SAP1. Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. Interacts with SIRT7.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ELK4

Mutations

Mutation(s) distribution

Mutations table