FEATURES

FAMILY

DESCRIPTION

Also known as T2EA_HUMAN, GTF2E1, TF2E1. Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Tetramer of two alpha and two beta chains (PubMed:1956398). Interacts with TAF6/TAFII80 (PubMed:7667268). Interacts with ATF7IP (PubMed:19106100). Interacts with SND1 (PubMed:7651391).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GTF2E1

General transcription factor IIE subunit 1

Mutations

Mutation(s) distribution

Mutations table

Search Mutation