FEATURES

FAMILY

DESCRIPTION

Also known as MPIP2_HUMAN, CDC25B, CDC25HU2. Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Interacts with MAPK14 and 14-3-3 proteins.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDC25B

M-phase inducer phosphatase 2

CDC25B

Molecular Synopsis