FEATURES

FAMILY

DESCRIPTION

Also known as METK2_HUMAN, MAT2A, AMS2, MATA2. Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAT2A

S-adenosylmethionine synthase isoform type-2

MAT2A

Molecular Synopsis