FEATURES

DESCRIPTION

Also known as FCG2B_HUMAN, FCGR2B, CD32, FCG2, IGFR2. Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FCGR2B

Low affinity immunoglobulin gamma Fc region receptor II-b

FCGR2B

Molecular Synopsis