FEATURES

FAMILY

DESCRIPTION

Also known as GRK4_HUMAN, GRK4, GPRK2L, GPRK4. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Interacts with DRD3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRK4

G protein-coupled receptor kinase 4

GRK4

Molecular Synopsis