FEATURES

FAMILY

DESCRIPTION

Also known as GBP2_HUMAN, GBP2. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GBP2

Mutations

Mutation(s) distribution

Mutations table