FEATURES

FAMILY

DESCRIPTION

Also known as NECT2_MOUSE, Nectin2, Mph, Pvr, Pvrl2, Pvs. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. Can form trans-heterodimers with NECTIN3 (PubMed:10744716, PubMed:22902367). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT (By similarity).

Also known as NECT2_MOUSE, Nectin2, Mph, Pvr, Pvrl2, Pvs. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to ...

EXTERNAL LINKS

Nectin2

Nectin-2

Nectin2

Molecular Synopsis