FEATURES

FAMILY

DESCRIPTION

Also known as NUDC_ECOLI, nudC, yjaD. mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:25533955, PubMed:27561816, PubMed:27428510). The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing (PubMed:25533955). Has preference for mRNAs with a 5'-end purine (PubMed:27428510). Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates, but uniquely prefers the reduced form of NADH (PubMed:7829480, PubMed:25533955). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

nudC

NAD-capped RNA hydrolase NudC

nudC

Molecular Synopsis