FEATURES

FAMILY

DESCRIPTION

Also known as A46_VAR67, A46R, A52R. Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation (By similarity). Interacts with host MYD88, TRF4, TICAM2 and MAL.

EXTERNAL LINKS

uniprot
enzyme classification

A46R, A52R

Protein A46

A46R, A52R

Structural Ligandability

Domains Chains

Distribution