FEATURES

FAMILY

DESCRIPTION

Also known as SKI2_YEAST, SKI2. RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon. Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation.

EXTERNAL LINKS

uniprot
enzyme classification

SKI2

Antiviral helicase SKI2

SKI2

Molecular Synopsis