FEATURES

FAMILY

DESCRIPTION

Also known as ACVL1_HUMAN, ACVRL1, ACVRLK1, ALK1. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACVRL1

Serine/threonine-protein kinase receptor R3

ACVRL1

Molecular Synopsis