FEATURES

DESCRIPTION

Also known as BACB_BACSU, bacB, ywfC. Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase (PubMed:15609023, PubMed:20052993). BacB catalyzes the allylic isomerization of the endocyclic-delta(4), delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E, 7R- and 3Z, 7R-olefins (E/Z ration of 3/1) of the exocyclic-delta(3), delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP) (PubMed:20052993, PubMed:22483065, PubMed:22765234, PubMed:19776011). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

bacB

H2HPP isomerase

bacB

Molecular Synopsis