FEATURES

DESCRIPTION

Also known as NUP82_YEAST, NUP82. Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved as part of the NUP82-NUP159-NSP1 subcomplex in nuclear mRNA and pre-ribosome export by acting as a linker tethering nucleoporins that are directly involved in nuclear transport to the NPC via its coiled-coil domain. Component of the nuclear pore complex (NPC) (PubMed:11689687). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP82 is part of the NUP82 subcomplex. This subcomplex is the base for interactions with NUP116 and GLE2, with NUP42 and GLE1 and with DYN2.

EXTERNAL LINKS

NUP82

Mutations

Mutation(s) distribution

Mutations table