FEATURES

FAMILY

DESCRIPTION

Also known as FYV10_YEAST, FYV10, GID9. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:22044534). Required for proteasome-dependent catabolite degradation of fructose-1, 6-bisphosphatase (FBP1) (PubMed:12686616, PubMed:22044534). May catalyze ubiquitination of target proteins in complex with RMD5 (Probable). Required for survival upon exposure to K1 killer toxin (PubMed:12663529). Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Interacts with RMD5/GID2; the interaction is direct (PubMed:22044534). Within the GID complex, interacts directly with VID28/GID5, GID8 and RMD5/GID2 (PubMed:22645139).

EXTERNAL LINKS

FYV10

Mutations

Mutation(s) distribution

Mutations table