FEATURES

FAMILY

DESCRIPTION

Also known as PLM2_PLAFX, PMII. During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:8844673, PubMed:11782538, PubMed:15574427). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN. The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage.

EXTERNAL LINKS

PMII

Plasmepsin II

PMII

Molecular Synopsis