FEATURES

DESCRIPTION

Also known as RP3A_RAT, Rph3a. Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:8617225, PubMed:16203731). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993). Plays also a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474). Interacts with RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B (By similarity). Interacts with RAB3A; this interaction recruits RPH3A to synaptic vesicules (PubMed:8617225, PubMed:10025402). Interacts (via C2B domain) with SNAP25 (PubMed:16203731, PubMed:28634303). Interacts with deubiquitinating enzyme CAND1; this interaction results in the deubiquitination of RPH3A (PubMed:29367474). Interacts with GRIN2A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (PubMed:26679993). Interacts with SNCA (By similarity).

EXTERNAL LINKS

Rph3a

Mutations

Mutation(s) distribution

Mutations table