FEATURES

FAMILY

DESCRIPTION

Also known as AQP4_RAT, Aqp4. Forms a water-specific channel (PubMed:7528931, PubMed:7509789, PubMed:19800950). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). Homotetramer (PubMed:16325200, PubMed:19406128). The tetramers can form oligomeric arrays in membranes (PubMed:18179769, PubMed:29055082). The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain (PubMed:29055082). Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion (PubMed:16325200). Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1 (By similarity).

EXTERNAL LINKS

Aqp4

Mutations

Mutation(s) distribution

Mutations table