FEATURES

FAMILY

DESCRIPTION

Also known as AL1A3_HUMAN, ALDH1A3, ALDH6. NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ALDH1A3

Aldehyde dehydrogenase family 1 member A3

Mutations

Mutation(s) distribution

Mutations table

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