FEATURES

FAMILY

dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family

DESCRIPTION

Also known as EAA4_HUMAN, SLC1A6, EAAT4. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Homotrimer.

EXTERNAL LINKS

SLC1A6

Excitatory amino acid transporter 4

Mutations

Mutation(s) distribution

Mutations table

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